Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients
Identifieur interne : 002732 ( Main/Corpus ); précédent : 002731; suivant : 002733Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients
Auteurs : U. Bonuccelli ; C. D'Avino ; N. Caraccio ; P. Del Guerra ; A. Casolaro ; N. Pavese ; P. Del Dotto ; F. MonzaniSource :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1999.
English descriptors
Abstract
Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term l-dopa and/or dopamine therapy on thyroid function. We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with l-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function. In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.
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DOI: 10.1016/S1353-8020(99)00010-3
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title><author><name sortKey="Bonuccelli, U" sort="Bonuccelli, U" uniqKey="Bonuccelli U" first="U." last="Bonuccelli">U. Bonuccelli</name><affiliation><mods:affiliation>E-mail: u.bonuccelli@neuro.med.unipi.it</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="D Avino, C" sort="D Avino, C" uniqKey="D Avino C" first="C." last="D'Avino">C. D'Avino</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Caraccio, N" sort="Caraccio, N" uniqKey="Caraccio N" first="N." last="Caraccio">N. Caraccio</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Del Guerra, P" sort="Del Guerra, P" uniqKey="Del Guerra P" first="P." last="Del Guerra">P. Del Guerra</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Casolaro, A" sort="Casolaro, A" uniqKey="Casolaro A" first="A." last="Casolaro">A. Casolaro</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Pavese, N" sort="Pavese, N" uniqKey="Pavese N" first="N." last="Pavese">N. Pavese</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Del Dotto, P" sort="Del Dotto, P" uniqKey="Del Dotto P" first="P." last="Del Dotto">P. Del Dotto</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Monzani, F" sort="Monzani, F" uniqKey="Monzani F" first="F." last="Monzani">F. Monzani</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:859C85B864BCAD3EB10212D8784CE1DDACC6C6C9</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S1353-8020(99)00010-3</idno><idno type="url">https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title><author><name sortKey="Bonuccelli, U" sort="Bonuccelli, U" uniqKey="Bonuccelli U" first="U." last="Bonuccelli">U. Bonuccelli</name><affiliation><mods:affiliation>E-mail: u.bonuccelli@neuro.med.unipi.it</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="D Avino, C" sort="D Avino, C" uniqKey="D Avino C" first="C." last="D'Avino">C. D'Avino</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Caraccio, N" sort="Caraccio, N" uniqKey="Caraccio N" first="N." last="Caraccio">N. Caraccio</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Del Guerra, P" sort="Del Guerra, P" uniqKey="Del Guerra P" first="P." last="Del Guerra">P. Del Guerra</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Casolaro, A" sort="Casolaro, A" uniqKey="Casolaro A" first="A." last="Casolaro">A. Casolaro</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author><author><name sortKey="Pavese, N" sort="Pavese, N" uniqKey="Pavese N" first="N." last="Pavese">N. Pavese</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Del Dotto, P" sort="Del Dotto, P" uniqKey="Del Dotto P" first="P." last="Del Dotto">P. Del Dotto</name><affiliation><mods:affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Monzani, F" sort="Monzani, F" uniqKey="Monzani F" first="F." last="Monzani">F. Monzani</name><affiliation><mods:affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="53">53</biblScope></imprint><idno type="ISSN">1353-8020</idno></series><idno type="istex">859C85B864BCAD3EB10212D8784CE1DDACC6C6C9</idno><idno type="DOI">10.1016/S1353-8020(99)00010-3</idno><idno type="PII">S1353-8020(99)00010-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autoimmune thyroid diseases</term><term>Parkinson's disease</term><term>Thyroid hormones</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term l-dopa and/or dopamine therapy on thyroid function. We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with l-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function. In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>U. Bonuccelli</name><affiliations><json:string>E-mail: u.bonuccelli@neuro.med.unipi.it</json:string><json:string>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</json:string></affiliations></json:item><json:item><name>C. D'Avino</name><affiliations><json:string>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</json:string></affiliations></json:item><json:item><name>N. Caraccio</name><affiliations><json:string>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</json:string></affiliations></json:item><json:item><name>P. Del Guerra</name><affiliations><json:string>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</json:string></affiliations></json:item><json:item><name>A. Casolaro</name><affiliations><json:string>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</json:string></affiliations></json:item><json:item><name>N. Pavese</name><affiliations><json:string>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</json:string></affiliations></json:item><json:item><name>P. Del Dotto</name><affiliations><json:string>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</json:string></affiliations></json:item><json:item><name>F. Monzani</name><affiliations><json:string>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Thyroid hormones</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Autoimmune thyroid diseases</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term l-dopa and/or dopamine therapy on thyroid function. We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with l-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function. In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.</abstract><qualityIndicators><score>4.979</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1233</abstractCharCount><pdfWordCount>2831</pdfWordCount><pdfCharCount>18500</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>179</abstractWordCount></qualityIndicators><title>Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title><pii><json:string>S1353-8020(99)00010-3</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>5</volume><pii><json:string>S1353-8020(00)X0015-6</json:string></pii><pages><last>53</last><first>49</first></pages><issn><json:string>1353-8020</json:string></issn><issue>1–2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Parkinsonism and Related Disorders</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>CLINICAL NEUROLOGY</json:string></wos></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S1353-8020(99)00010-3</json:string></doi><id>859C85B864BCAD3EB10212D8784CE1DDACC6C6C9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1999</date></publicationStmt><notesStmt><note type="content">Table 1: Clinical features of the 101 patients with idiopathic Parkinson's disease (PD) and of the 70 neurological controls (NC), admitted to the study</note><note type="content">Table 2: Thyroid function and prevalence of antithyroid autoantibodies in Parkinson's disease patients (PD) and neurological controls (NC)</note><note type="content">Table 3: Serum thyroid hormone (pmol/l) and TSH (mlU/l) among patients with idiopathic Parkinson's disease (PD) and neurological controls (NC) before (101 PD; 70 NC) and after (90 PD; 63 NC) having excluded dysthyroid patients. Data are expressed as the mean±SD</note><note type="content">Table 4: Serum thyroid hormone (pmol/l) and TSH (mlU/l) among 90 euthyroid patients with idiopathic Parkinson's disease: DA: patients on l-dopa and/or dopaminergic drugs; DA ago: dopamine agonist; non-DA: untreated patients. Data are expressed as the mean±S.D. Differences are not statistically significant</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title><author><persName><forename type="first">U.</forename><surname>Bonuccelli</surname></persName><email>u.bonuccelli@neuro.med.unipi.it</email><note type="correspondence"><p>Corresponding author. Tel.: +39-050-992561; fax: +39-050-992563.</p></note><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation></author><author><persName><forename type="first">C.</forename><surname>D'Avino</surname></persName><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation></author><author><persName><forename type="first">N.</forename><surname>Caraccio</surname></persName><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation></author><author><persName><forename type="first">P.</forename><surname>Del Guerra</surname></persName><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation></author><author><persName><forename type="first">A.</forename><surname>Casolaro</surname></persName><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation></author><author><persName><forename type="first">N.</forename><surname>Pavese</surname></persName><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation></author><author><persName><forename type="first">P.</forename><surname>Del Dotto</surname></persName><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation></author><author><persName><forename type="first">F.</forename><surname>Monzani</surname></persName><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation></author></analytic><monogr><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="pISSN">1353-8020</idno><idno type="PII">S1353-8020(00)X0015-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">5</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="53">53</biblScope></imprint></monogr><idno type="istex">859C85B864BCAD3EB10212D8784CE1DDACC6C6C9</idno><idno type="DOI">10.1016/S1353-8020(99)00010-3</idno><idno type="PII">S1353-8020(99)00010-3</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term l-dopa and/or dopamine therapy on thyroid function. We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with l-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function. In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>Thyroid hormones</term></item><item><term>Autoimmune thyroid diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-02-01">Registration</change><change when="1999-02-01">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>PRD</jid><aid>148</aid><ce:pii>S1353-8020(99)00010-3</ce:pii><ce:doi>10.1016/S1353-8020(99)00010-3</ce:doi><ce:copyright type="unknown" year="1999"></ce:copyright></item-info><head><ce:title>Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</ce:title><ce:author-group><ce:author><ce:given-name>U.</ce:given-name><ce:surname>Bonuccelli</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>u.bonuccelli@neuro.med.unipi.it</ce:e-address></ce:author><ce:author><ce:given-name>C.</ce:given-name><ce:surname>D'Avino</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>N.</ce:given-name><ce:surname>Caraccio</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Del Guerra</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Casolaro</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>N.</ce:given-name><ce:surname>Pavese</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Del Dotto</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Monzani</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +39-050-992561; fax: +39-050-992563.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="23" month="6" year="1998"></ce:date-received><ce:date-revised day="1" month="2" year="1999"></ce:date-revised><ce:date-accepted day="1" month="2" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term <ce:small-caps>l</ce:small-caps>-dopa and/or dopamine therapy on thyroid function.</ce:simple-para><ce:simple-para>We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with <ce:small-caps>l</ce:small-caps>-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function.</ce:simple-para><ce:simple-para>In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Thyroid hormones</ce:text></ce:keyword><ce:keyword><ce:text>Autoimmune thyroid diseases</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Thyroid function and autoimmunity in Parkinson's disease: a study of 101 patients</title></titleInfo><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Bonuccelli</namePart><affiliation>E-mail: u.bonuccelli@neuro.med.unipi.it</affiliation><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation><description>Corresponding author. Tel.: +39-050-992561; fax: +39-050-992563.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">D'Avino</namePart><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Caraccio</namePart><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Del Guerra</namePart><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Casolaro</namePart><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Pavese</namePart><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Del Dotto</namePart><affiliation>Department of Neuroscience, Section of Neurology (U.B., C.D.A., N.P., P.D.D.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Monzani</namePart><affiliation>Department of Internal Medicine-Section of Metabolism (F.M., P.D.G., N.C., A.C.), University of Pisa, Via Roma, 67 I-56126 Pisa, Italy.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateValid encoding="w3cdtf">1999-02-01</dateValid><dateModified encoding="w3cdtf">1999-02-01</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Thyroid disease is the endocrine dysfunction most frequently reported in association with idiopathic Parkinson's disease (PD). The aim of this study was to assess thyroid autoimmunity and function in PD, and to verify the effect of long term l-dopa and/or dopamine therapy on thyroid function. We studied 101 consecutive PD outpatients and seventy age- and sex-matched neurological non-PD patients as controls. They were evaluated for free thyroid hormones, TSH and thyroid autoantibodies. No significant difference in the prevalence of thyroid autoimmunity and dysfunction was found between PD patients and neurological controls (10.8% in PD patients vs 10% in neurological controls). Further, treatment with l-dopa and/or dopaminergic drugs and the stage of Parkinson's disease did not affect thyroid function. In conclusion, the prevalence of thyroid autoimmunity in PD patients appeared similar to that as described in the general population, though thyroid dysfunction was observed in over than 10% of PD patients. Indeed, neurologists should be alerted to the possible complications arising from thyroid dysfunction in Parkinson's disease, but thyroid function tests should be performed only when justified on clinical grounds.</abstract><note type="content">Table 1: Clinical features of the 101 patients with idiopathic Parkinson's disease (PD) and of the 70 neurological controls (NC), admitted to the study</note><note type="content">Table 2: Thyroid function and prevalence of antithyroid autoantibodies in Parkinson's disease patients (PD) and neurological controls (NC)</note><note type="content">Table 3: Serum thyroid hormone (pmol/l) and TSH (mlU/l) among patients with idiopathic Parkinson's disease (PD) and neurological controls (NC) before (101 PD; 70 NC) and after (90 PD; 63 NC) having excluded dysthyroid patients. Data are expressed as the mean±SD</note><note type="content">Table 4: Serum thyroid hormone (pmol/l) and TSH (mlU/l) among 90 euthyroid patients with idiopathic Parkinson's disease: DA: patients on l-dopa and/or dopaminergic drugs; DA ago: dopamine agonist; non-DA: untreated patients. Data are expressed as the mean±S.D. Differences are not statistically significant</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Thyroid hormones</topic><topic>Autoimmune thyroid diseases</topic></subject><relatedItem type="host"><titleInfo><title>Parkinsonism and Related Disorders</title></titleInfo><titleInfo type="abbreviated"><title>PRD</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199904</dateIssued></originInfo><identifier type="ISSN">1353-8020</identifier><identifier type="PII">S1353-8020(00)X0015-6</identifier><part><date>199904</date><detail type="volume"><number>5</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>86</end></extent><extent unit="pages"><start>49</start><end>53</end></extent></part></relatedItem><identifier type="istex">859C85B864BCAD3EB10212D8784CE1DDACC6C6C9</identifier><identifier type="DOI">10.1016/S1353-8020(99)00010-3</identifier><identifier type="PII">S1353-8020(99)00010-3</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/859C85B864BCAD3EB10212D8784CE1DDACC6C6C9/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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